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Radiotherapy for dogs and cats

🐾 What is radiotherapy?

 

🐾 What are the main indications?

 

 

1. Conventional radiotherapy

 

  • Electron treatment
  • Photon treatment and 3D conformal technique
  • IMRT or VMAT treatment

 

 

2. Stereotaxic radiotherapy

 

 

3. Radiotherapy treatment pathway

 

  • Imaging and treatment plan preparation
  • Dosimetry and quality controls
  • Setting up and conducting radiotherapy sessions
  • What are the side effects of radiotherapy?
  • What are the contraindications?
  • And the preparation…?

What is radiotherapy?

Radiation oncology (radiotherapy) is a medical discipline in oncology that uses “rays” for the local and/or regional treatment of cancers. This discipline relies on the expertise of our specialists, still rare in Europe, and on a very specific type of equipment: a linear accelerator (Linac).

 

The treatment goals can be definitive ("curative intent") or more palliative, depending on the cases and the protocols chosen.

 

What are the main indications?

  • Definitive treatment complementary to surgery (= adjuvant therapy) for tumours excised with infiltrated margins ("dirty" margins).
  • Definitive local treatment of radiosensitive lesions (some malignant and benign tumours, but also some non-tumour inflammatory diseases)
  • Palliative treatment of incurable tumours for temporary control of the disease, or control of symptoms (e.g. pain, obstructions, etc.)

 

1. Conventional radiotherapy

Conventional radiotherapy includes different radiation techniques, more or less complex, distributed in “standard” doses that aim to cover both the target lesion and nearby microscopic margins. These treatments are typically carried out in 4 to 20 sessions, depending on the treatment goal.

Electron therapy

Electron therapy uses a type of radiation (electrons) whose energy will be deposited on the surface, without deep irradiation. This type of treatment is indicated in the case of superficial tumours (skin or subcutaneous), especially if organs at risk are present under the treated target (e.g. chest or abdominal wall). In the latter case, there will not only be an optimal dose on the surface, but an optimized avoidance of healthy tissues in depth.

Photon treatment and 3D conformal technique

A majority of deeper or complex shaped lesions (or targets) will be more ideally treated by photon therapy (X-rays). The treatment plan will then be more or less complex, depending on the location of the lesion and the proximity of tissues at risk. A simple 3D conformal treatment is suitable for the treatment of target volume lesions without proximity to particularly at-risk organs or some wide-field techniques, or the implementation of low-intensity, palliative treatment.

  • Mandibular tumours
  • Complex subcutaneous tumours (limbs)
  • Bone tumours (palliative)
  • Multicentric or abdominal lymphomas
  • Meningitis of unknown origin

IMRT or VMAT treatment

When greater precision is required, particularly for target dose optimization and/or avoidance of organs at risk, dose-modulated treatment techniques (IMRT or VMAT) are indicated. These high precision techniques require greater quality controls to ensure perfect treatment delivery. The greater precision allows in some cases to reduce the number of sessions without compromising the quality of the therapy (hypofractionation).

  • Nasal or maxillary tumours
  • Cervical tumours
  • Brain, pituitary or spinal tumours
  • Intra-thoracic tumours (thymoma, tumours of the base of the heart, etc.)
  • Intra-abdominal tumours (adrenal tumours, bladder, urethral or prostate tumours, anal sac tumours, etc.)

2. Stereotaxic radiotherapy

In some very specific cases (early stages of some pathologies), a new technique with very high dose conformation makes it possible to reduce protocols to only 1 to 5 consecutive sessions. This approach is definitive and uses “ablative” doses of radiation. At these doses, only the target lesion is exposed and healthy tissues beyond 1-3 mm from the lesion must be spared, at the risk of local complications. This technique is based on very complex planning and very restrictive quality control procedures in order to ensure maximum safety for these patients.

  • Nasal tumours
  • Brain, pituitary or spinal tumours
  • Bone tumours
  • Other indications currently being validated

3. Radiotherapy treatment pathway

The care pathway begins with a consultation in medical oncology or radiation oncology for case assessment and validation of the indication after diagnosis and extension assessment. During this consultation, the prognoses, protocol options, often multiple, and logistical and financial aspects are discussed.

  • Imaging and treatment plan preparation
  • Dosimetry and quality controls
  • Setting up and conducting radiotherapy sessions
  • What are the side effects of radiotherapy?
  • What are the contraindications?
  • And the preparation…?

Imaging and treatment plan preparation

Most often, an imaging examination is necessary for the planning (simulation) of radiotherapy. During the scan, the patient is positioned as for their radiotherapy sessions using tools that will be specific to them for the entire therapy. In some cases where the tumour is not very visible on the scan, an MRI examination will be associated to increase the precision of the contouring. The CT and MRI series can be merged.

Chat scanner Imagerie Oncovet

 

Dosimetry and quality controls

Dosimetry is performed using specific software by the specialist. It takes several hours to complete these treatment plans and dose calculations. Once the plan has been validated, quality control procedures are performed to verify that the equipment has the capacity to deliver the treatment plan with a very low margin of error. These initial tests are performed without the patient.

Setting up and conducting radiotherapy sessions

Then, during the radiotherapy sessions, new tests, with the patient, are still carried out at each session to confirm the perfect positioning of the animal for the programmed treatment plan.

Each session is carried out under a short general anaesthesia (15-20 minutes) because no one can stay in the treatment room. The patient is monitored by camera and the adapted cardio-respiratory monitoring.

The awakening is quick following a radiotherapy session. No sensation is felt during the rays.

An end-of-treatment consultation is organized with the specialist to discuss the side effects and the follow-up plan.

asv et chien radiotherapie

What are the side effects of radiotherapy?

Side effects are divided into 2 categories, acute effects and late complications:

  • Acute effects mainly concern the skin and mucous membranes and appear at the end of therapy and can progress for 2–3 weeks after therapy. These effects are normal in the case of intensive treatments and rarer in the case of less fractionated treatments. They are treated by symptomatic treatment (anti-inflammatories, painkillers, antibiotics, and healing ointments). A complete recovery is almost systematic.
  • Late complications affecting other tissues (dermis, nervous tissue, bones, muscles, lenses, retina, etc.) are irreversible and may only appear after several years. The risk of this type of side effect is low in pets whose natural survival, even in the event of recovery, is often too short.

What are the contraindications?

Contraindication related to repeated anaesthesia (advanced heart disease; severe concomitant renal diseases).

And the preparation…?

Animal fasted for at least 10 hours. It can drink up to 2 hours before the examination and MUST take its medication.

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